resolutionmini

 

mise à jour du 21 août 2003
European Journal of Pharmacology
1983; 86; 279-282
lexique
Cycloheximide prevents apomporphine induced yawning, penile erection and genital grooming in rats
Serra G, Fratta W, Collu M, Napoli-Farris L, Gessa GL
Institute of pharmacology, University of Cagliari, Italy
Tous les travaux de MR Melis & A Argiolas 
Tous les travaux de M Eguibar & G Holmgren

Chat-logomini

Introduction :
 
The administration of small doses of apomorphine in rats produces a behavioural syndrome characterized by decreased locomotor activity, yawning, and penile erection. these effects have been attributed to stimulation of dopamine (DA) receptors in the CNS.
A great deal of evidence indicates that DA and peptides interact at pituary and CNS levels. Thus, peptides may coexist with DA in the same neurons, peptides may influence DA synthesis and release. Moreover, the release of different peptides cause behavioural effects in common with apomorphine. Thses observations led us to study whether protein synthesis inhibition might alter the behavioral effects of apomorphine.
 
The present results indicate that cycloheximide inhibits the yawning, penile erection, and genital grooming induced by small doses of apomorphine, but fails to alter the stereotypy induced by higher doses of this drug. [...]
 
Discussion :
 
The present results show that cycloheximide prevents the yawning, penile erection and genital grooming induced by a low dose of apomorphine but fails to modify the stereotyped behaviour induced by a relatively high dose of this drug. Cycloheximide inhibition of apomorphine effect was present from 1 to 6 h, when brain protein synthesis was reduced by about 50%, while 12 h after cycloheximide treatment, both brain protein synthesis and the behavioural effects of apomorphine returned to normal values.
 
These observations suggest that the effect of cycloheximide on apomorphine-induced behavioural changes is secondary to its inhibitory effect on brain protein synthesis, rather than to its sedative effect. The latter is still present at 12 h after treatment when the antagonistic effect is no longer evident.
 
Our results suggest that protein synthesis is required for behavioural effects induced by the low doses of apomorphine, but not for the stereotyped behaviour induced by the high doses of the drug.
 
There is considerable experimental evidence suggesting the existence of two kinds of DA receptors in the brain which mediate opposite behavioural responses. Stimulation of motor activity and stereotypy elicited by high doses of apomorphine are considered to be mediated by striatal or mesolimbic postsynaptic DA receptors. On the contrary, it has been suggested that the behavioural syndrome induced by low doses of apomorphine is the behavioural consequence of the inhibition of dopaminergic transmission mediated by the stimulation of DA autoreceptors.
 
The fact that active protein synthesis is needed for such behavioural responses suggests that the inhibition of DA transmission might result in the release of some active peptides. These might be identified with prolactin and/or MSH, both of which are under tonic inhibition control by DA and have been shown to produce grooming in rats. Finally MSH shares with apomorphine the ability to produce penile erection and yawning.
 
Gessa GL Stretchings and yawnings induced by adrenocorticotrophic hormone Nature 23/07/1966; 5047; 426-427
Gessa GL Stretching and yawning movements after intracerebral injection of ACTH Revue Canadienne Bioliologie; 1967, 26, 3, 229-236
Hipolide DC, Lobo LL, De Medeiros R, Neumann B, Tufik S Treatment with dexamethasone alters yawning behavior induced by cholinergic but not dopaminergic agonist Physiol Behav 1999; 65; 4-5; 829-32
Kimura H, Yamada K, Nagashima M, Matsumoto S, Ishii Y, Yoshida S, Fujii K, Furukawa T Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats. Pharmacol Biochem Behav 1992; 43; 4; 985-91
Kimura H, Yamada K, Nagashima M, Furukawa T Involvement of catecholamine receptor activities in modulating the incidence of yawning in rats.Pharmacol Biochem Behav 1996; 53; 4; 1017-21
Laing J, Ogilvie R EEG correlats of yawning during sleep onset Sleep Research 1988; 17; 98
Lobo LL, Neumann BG, Eidman DS, Tufik S Effects of REM sleep deprivation of ACTH-induced yawning. Pharmacology 1990; 40; 3; 174-8
Molgilnicka E REM sleep deprivation changes behavioral response to catecholaminergic and serotoninergic receptor activation in rats Pharmacol Biochem Behav 1981; 15; 1; 149-151
Morelli M et al Antagonism of apomorphine-induced yawning by SCH 23390: Evidence against the autoreceptor hypothesis
Serra G , Collu M and Gessa GL Yawning is elicited by D2 dopamine agonists but is blocked by D1 antagonist Psychopharmacology 1987; 91; 330-337
Serra G, Gessa GL Hypophysectomy prevents yawning and penile erection but not hypomotility induced by apomorphine Pharmacology Biochemistry & Behavior 1983; 19; 917-919
Serra G et al Cycloheximide prevents apomporphine induced yawning, penile erection and genital grooming in rats European Journal of Pharmacology 1983; 86; 279-282
Stahle L Do autoreceptors mediate dopamine agonist-induced yawning and suppression of exploration ? a critical review. Psychopharmacology 1992; 106; 1-13
Neumann BG, Troncone LR, Braz S, Tufik S Modifications on dopaminergic and cholinergic systems induced by the water tank technique: analysis through yawning behavior Arch Int Pharmacodyn Ther 1990; 308; 32-8
Stahle L Do autoreceptors mediate dopamine agonist-induced yawning and suppression of exploration ? a critical review. Psychopharmacology 1992; 106; 1-13
Tufik S Does REM sleep deprivation induce subsensitivity of presynaptic dopamine or postsynaptic acetylcholine receptors in the rat brain? European Journal of Pharrnacology 1987; 140; 215-219
Tufik S Effects of stress on drug induced yawning Physiology & behavior 1995; 8; 1; 1881-18
 
-Yamada K, Furukawa T Direct evidence for involvement of dopaminergic inhibition and cholinergic activation in yawning Psychopharmacology 1980; 67; 39-43
-Yamada K, Furukawa T The yawning elicited by alpha-melanocyte-stimulating hormone involves serotonergic -dopaminergic - cholinergic neuron link in rats Naunyn-Schmiedeberg's Arch Pharmacol 1981; 316; 155 -160
-Yamada K et al Involvement of septal and striatal dopamine D2 receptors in yawning behavior in rats Psychopharmacology 1986; 90; 9-13
-Yamada K et al Possible involvement of differing classes of dopamine d2 receptors in yawning and stereotypy in rats Psychopharmacology 1990; 100; 141-144
-Yamada K, Furukawa T Behavioral studies on central dopaminergic neurons. especially jumping, stretching, body shaking and yawning behavior J PharmacoBio dynamics 1980; 3; S16-S18
-Yamada K, Matsumoto S, Nagashima M, Kumagai M, Matsuo N, Furukawa T Stimulatory effects of beta-adrenoceptor blockers on the yawning induced by dopaminergic and cholinergic agonists in rats. Japanese J Pharmacology 1987; 43; supp53p
-Yamada K, S Matsumoto, M Nagashima, K Shirakawa, T Furukawa Potentiation of yawning responses to the dopamine receptor agonists B-HT 920 and SND 919 by pindolol in the rat J Neural Transm [GenSect] 1990; 79; 19-24
-Fugikawa M; Yamada K; Nagashima M; Furukawa T Involvement of beta-adrenoreceptors in regulation of the yawning induced by neuropeptides; oxytocin and alpha-melanocytes stimuling hormone in rats. Pharmacol Biochem Behav 1995; 50; 339-343
-Furukawa T Yawning behavior for preclinical drug evaluation Meth Find Exp Clin Phamacol 1996; 18; 2; 141-155
-Kimura H; Yamada K; Nagashima M; Matsumoto S Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats.Pharmacol Biochem Behav 1992; 43; 4; 985-91
-Kimura H; Yamada K; Nagashima M; Furukawa T Involvement of catecholamine receptor activities in modulating the incidence of yawning in rats.Pharmacol Biochem Behav 1996; 53(; 4; 1017-21
Ogura H, Kosasa T, Kuriya Y, Yamanishi Y Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats. Eur J Pharmacol. 2001; 415; 2-3; 157-64
-Matsumoto S, Yamada K, Nagashima M, Matsuo N, Shirakawa K, Furukawa T Potentiation by serotonergic inhibition of yawning induced by dopamine receptor agonists in rats.Pharmacol Biochem Behav 1989; 32; 3; 815-8
-Serra G , Collu M and Gessa GL Yawning is elicited by D2 dopamine agonists but is blocked by D1 antagonist Psychopharmacology 1987; 91; 330-337
-Serra G, Gessa GL Hypophysectomy prevents yawning and penile erection but not hypomotility induced by apomorphine Pharmacology Biochemistry & Behavior 1983; 19; 917-919
-Serra G et al Cycloheximide prevents apomporphine induced yawning, penile erection and genital grooming in rats European Journal of Pharmacology1983; 86; 279-282
-Kostrzewa RM and R Brus Is dopamine-agonist induced yawning behavior a D3 mediated event? Life Sci 1991; 48; 26; 129