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mise à jour du
23 octobre 2005
Japanese J Pharmacology
1987; 43; supp53p
Stimulatory effects of beta-adrenoceptor blockers on the yawning induced by dopaminergic
and cholinergic agonists in rats
Yamada K, Matsumoto S, Nagashima M,
Kumagai M, Matsuo N, Furukawa T
Department of Pharmacology. School of Medicine. Fukuoka University, Japan.

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We have reported that dopamine receptor agonists elicit yawning by stimulating dopamine D-2 receptors, and striatal and septal dopaminergic systems may be related to the occurrence of yawning. Cholinergic agonists also evoke yawning. (Psychopharmacology, 90, p9. 1986).
 
In the present study, effects of beta-adrenoceptor antagonists on yawning were investigated. Yawning was evoked by apomorphine and piribedil but not by SK&F-38393, a dopamine D-1 receptor agonist. The apomorphine induced yawning was increased by dl-propranolol and pindolol which did not induce yawning but not by prazosin. SK&F-38393 in combination with beta-adrenoceptor antagonists did not induce yawning.
 
The yawning elicited by apomorphine or piribedil in combination with pindolol was suppressed by spiperone and YM-09151-2, dopamine D2 receptor antagonists, and scopolamine but not by SCH-23390, a dopamine D-1 receptor antagonist. Pindolol also enhanced the yawning induced by physostigmine and pilocarpine, and the enhanced yawning was inhibited by scopolamine but not by spiperone, YM-09l5l-2 and SCH-23390. The present results suggest that dopamine D-2 receptors are involved in the yawning induced by dopaminergic agonists and beta-adrenoceptor blockade exerts a stimulatory effect in the occurrence of yawning.
 
-Fugikawa M; Yamada K; Nagashima M; Furukawa T Involvement of beta-adrenoreceptors in regulation of the yawning induced by neuropeptides; oxytocin and alpha-melanocytes stimuling hormone in rats. Pharmacol Biochem Behav 1995; 50; 339-343
-Furukawa T Yawning behavior for preclinical drug evaluation Meth Find Exp Clin Phamacol 1996; 18; 2; 141-155
-Kimura H; Yamada K; Nagashima M; Matsumoto S Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats.Pharmacol Biochem Behav 1992; 43; 4; 985-91
-Kimura H; Yamada K; Nagashima M; Furukawa T Involvement of catecholamine receptor activities in modulating the incidence of yawning in rats.Pharmacol Biochem Behav 1996; 53(; 4; 1017-21
Ogura H, Kosasa T, Kuriya Y, Yamanishi Y Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats. Eur J Pharmacol. 2001; 415; 2-3; 157-64
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-Yamada K, Furukawa T Direct evidence for involvement of dopaminergic inhibition and cholinergic activation in yawning Psychopharmacology 1980; 67; 39-43
-Yamada K, Furukawa T The yawning elicited by alpha-melanocyte-stimulating hormone involves serotonergic -dopaminergic - cholinergic neuron link in rats Naunyn-Schmiedeberg's Arch Pharmacol 1981; 316; 155 -160
-Yamada K et al Involvement of septal and striatal dopamine D2 receptors in yawning behavior in rats Psychopharmacology 1986; 90; 9-13
-Yamada K et al Possible involvement of differing classes of dopamine d2 receptors in yawning and stereotypy in rats Psychopharmacology 1990; 100; 141-144
-Yamada K, Furukawa T Behavioral studies on central dopaminergic neurons. especially jumping, stretching, body shaking and yawning behavior J PharmacoBio dynamics 1980; 3; S16-S18
-Yamada K, Matsumoto S, Nagashima M, Kumagai M, Matsuo N, Furukawa T Stimulatory effects of beta-adrenoceptor blockers on the yawning induced by dopaminergic and cholinergic agonists in rats. Japanese J Pharmacology 1987; 43; supp53p
-Yamada K, S Matsumoto, M Nagashima, K Shirakawa, T Furukawa Potentiation of yawning responses to the dopamine receptor agonists B-HT 920 and SND 919 by pindolol in the rat J Neural Transm [GenSect] 1990; 79; 19-24