 - Androgenes
influence on yawning behavior
-
- In the adult rhesus monkey, yawning is an
androgen-dependent sexually dimorphic behavior
with males yawning more frequently than do
females reflecting sex differences in
circulating androgens. Studies in a variety of
species indicate that yawning is mediated by
various neurochemicals including dopamine,
serotonin, and oxytocin. In rhesus monkeys,
exogenous androgen reliably induces yawning in
females to male-like levels. This study
investigated whether flutamide, a nonsteroidal
anti-androgen, reverses yawning induced by
exogenous androgen administration in adult
female rhesus monkeys. Six adult female rhesus
monkeys were given chronic DHT alone and in
combination with daily injections of flutamide
and observed for yawning behavior. Treatment
with DHT alone significantly increased yawning
from 0.3 yawns per 30 min at the pretreatment
baseline to 4.7 yawns per 30 min. Concurrent
administration of flutamide significantly
reduced the rate of yawning to 1.9 yawns per 30
min. These data indicate that flutamide is an
effective tool for blocking the central effects
of androgens in rhesus monkey females and that
androgens regulate yawning similarly in both
males and females. Androgenes modulate the
activity of the oxytocin's neurons of
the PVN of the
hypothalamus.
-
- Les
androgènes influencent le nombre des
bâillements
-
- Chez le singe Macaque rhésus, le
bâillement est sexuellement
différencié car dépendant
du taux d'androgènes circulants: les
mâles bâillent plus que les
femelles. La neurophysiologie du
bâillement, étudiée chez de
nombreuses espèces animales, implique
l'intervention de nombreux
neuromédiateurs: dopamine,
sérotonine, et l'oxytocine etc. Chez le
singe Macaque rhésus, l'administration
d'androgènes à une femelle, afin
d'obtenir un taux circulant comparable à
celui d'un mâle, induit des
bâillements en nombre comparable à
celui du mâle. Ce travail a cherché
à montrer l'effet d'un
anti-testostérone non
stéroïdien, le flutamide, chez une
femelle Macaque rhésus,
prélablement traitée par
testostérone. Effectivement, le flutamide
s'est montré capable de supprimer l'effet
de la testostérone, et de faire
disparaître les bâillements
prélablement induits. Ceci montre un
effet central du flutamide qui se
révèle ainsi comme un moyen
pharmacologique pouvant modifier des
comportements hormonodépendants. La
testostérone, tant chez le mâle que
chez la femelle, semble agir en modulant
l'activté des neurones oxytocinergiques
du noyau paraventriculaire de
l'hypothalamus.
 - Hormonal
and genetic influences on arousal sexual and
otherwise Pfaff D, Frohlich
J.Trends Neurosci. 2002; .25; 1;
45-50
- Precision in mouse behavior genetics Pfaff D
PNAS 2001; 98; 11;
5957-5960
- Sex
hormone influences on yawning behavior
Holmgren R, Holmgren U, Rodriguez
R Acta Neurobiol Exp 1980; 40;
515-519
- Behavioral
effects of an antiandrogen in adult male rhesus
Macaques Deputte BL, Johnson J, Hempel M,
Scheffler G Hormones and
Behavior 1994; 28; 155-164
- Storage and
display of odour by male Chiroptera Voigt
CC, von Helversen O Behav Ecol
Sociobiol 1999; 47; 29-40
- The
influence of age, sex, rank on yawning behavior
in two species of macaques Troisi A, Aureli
F Ethology 1990; 86;
303-310
- Do men
yawn more then women ? Schino G, Aureli
F Ethol. sociobiol. 1989; 10;
375-378
- Androgen-induced
yawning in rhesus monkey females is reversed
with a nonsteroidal anti-androgen Graves FC,
Wallen K Hormones and Behavior
2005, in press
- Threshold
for behavioral response to testosterone in old
castrated Male Rhesus Macaques Phoenix CH,
Kathleen C Biology of
reproduction1986; 35, 918-926
- Androgenic
influences on apomorphine-induced yawning in
rats Berendsen HG.
Behavioral & Neural Biology 1981; 33;
123-128
- Testosterone
potentiation of the effectiveness of ACTH on the
induction of the strech-yawning syndrome in male
Guinea Pigs Rodriguez-Sierra J
Hormones and Behavior 1981; 15;
77-85
- Apomorphine
facilitates male sexual behavior of Rhesus
Monkeys Pomerantz SM.
Pharmacol Biochem Behavior 1990; 35;
659-664
- Apomorphine
and Oxytocin induced penile erection and yawning
in intact and castrated male rats : effect of
sexual steroids Melis MR, Argiolas
A. Neuroendocrinology 1994;59;
349-354
- Genomic
and non-genomic effects of steroïds on
neuronal activity McEwen BS
Trends Pharmacol Sci 1991;
12:141-147
- Sexual
behavior in adult gonadectomized female
pseudohermaphrodite, female, and male Rhesus
Macaques treated with estradiol benzoate and
testosterone propionate Phoenix CH, Chambers
KC J Comp Physiol Psychol 1982,
96, 5; 823-833
- Gonadal
hormones and behavior of normal and
pseudohermaphroditic nonhuman female
primates Goy, Resko Rec
Progr Horm Res 1972; 28; 707-733
- Opiate-androgen
interactions in drug-induced yawning and penile
erections in the rats Berendsen HG, Gower AJ
Neuroendocrinology 1986; 42;
185-190
- The
conditioned response erection (CRE) a new
approach to modelling erectile responses in the
rat Brien SE, Wilson E, Heaton JP, Adams
MA. Int J Impot Res. 2000;12; 2;
91-96.
- Effects
of castration and exogenous testosterone
supplementation in an animal model of penile
erection Heaton JP, Varrin S
J. J Urol 1994; 151; 3;
797-800
- Heterosexual,
autosexual and social behavior of adult male
rhesus monkeys with medial preoptic-anterior
hypothalamic lesions. Slimp JC, Hart BL, Goy
RW. Brain Res.
1978;142(1):105-122.
-
- Brain
and sexual behavior K Larsson S
Ahlenius Annals of the New York
Academy of Sciences 1999; 877;
292-308
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