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- mise à jour
du
- 15 décmbre
2025
- J Psychiatr Res.
- 2025;192:378-384
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- Prevalence
of SSRI-Related yawning and relationship with
clinical features in patients with major
depressive disorder: A prospective
study
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- Yõldõrõm YE, Yurtseven E, Aydõn PÇ,
Günver MG.
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- Iatrogenic
yawning
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- Abstract
- Background: Yawning, a common physiological
response, can significantly impact quality of
life when excessive. Although known as a side
effect of selective serotonin reuptake
inhibitors (SSRIs), its prevalence and
relationship with depression remain
underexplored.
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- Objective: This study investigates
the prevalence of SSRI-induced yawning in
patients with major depressive disorder (MDD)
and its association with clinical features.
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- Methods: We enrolled 150 patients
aged 18-65 diagnosed with MDD per DSM-5
criteria, who had not previously used SSRIs and
were prescribed SSRIs. Assessments included the
Beck Depression Inventory (BDI), Insomnia
Severity Index (ISI), UKU Side Effect Rating
Scale, and a Yawning Severity Assessment Form
developed by the researchers. Follow-up
evaluations were conducted one month after
initiating treatment.
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- Results: Of the initial cohort, 110
patients completed the follow-up.
Post-treatment, both BDI and ISI scores
significantly decreased (p < 0.001). Yawning
severity increased significantly (p = 0.010),
with the prevalence of excessive yawning rising
from 5.4 % to 15.4 %. Yawning severity was
positively correlated with BDI and ISI scores
both pre- and post-treatment, decreasing in
treatment responders and increasing
significantly among non-responders.
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- Discussion: This first prospective
study on the relationship between depression,
SSRI use, and yawning shows an increase in
yawning severity associated with SSRI use,
correlating with the severity of depression. The
observed association with treatment response
suggests a potential research direction, though
clinical relevance remains to be determined.
These findings underscore the importance for
clinicians to monitor yawning as a side effect
in patients diagnosed with MDD initiating
SSRI.
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- Dong
YY, Wang YG, Kuo SC, Chen CY, Yeh YW.
- Excessive Yawning Induced by Duloxetine in a
Patient With Depression With Successful
Agomelatine Substitution: A Case Report.
- Am J Ther. 2025 Nov 7.
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