Stimulatory
effects of beta-adrenoceptor blockers on the
yawning induced by dopaminergic
and
cholinergic agonists in rats
Yamada K, Matsumoto S, Nagashima M,
Kumagai M, Matsuo N, Furukawa T
Department of Pharmacology.
School of Medicine. Fukuoka University,
Japan.
We have reported that dopamine receptor
agonists elicit yawning by stimulating dopamine
D-2 receptors, and striatal and septal
dopaminergic systems may be related to the
occurrence of yawning. Cholinergic agonists also
evoke yawning. (Psychopharmacology, 90, p9.
1986).
In the present study, effects of
beta-adrenoceptor antagonists on yawning were
investigated. Yawning was evoked by apomorphine
and piribedil but not by SK&F-38393, a
dopamine D-1 receptor agonist. The apomorphine
induced yawning was increased by dl-propranolol
and pindolol which did not induce yawning but
not by prazosin. SK&F-38393 in combination
with beta-adrenoceptor antagonists did not
induce yawning.
The yawning elicited by apomorphine or
piribedil in combination with pindolol was
suppressed by spiperone and YM-09151-2, dopamine
D2 receptor antagonists, and scopolamine but not
by SCH-23390, a dopamine D-1 receptor
antagonist. Pindolol also enhanced the yawning
induced by physostigmine and pilocarpine, and
the enhanced yawning was inhibited by
scopolamine but not by spiperone, YM-09l5l-2 and
SCH-23390. The present results suggest that
dopamine D-2 receptors are involved in the
yawning induced by dopaminergic agonists and
beta-adrenoceptor blockade exerts a stimulatory
effect in the occurrence of yawning.
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