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mise à jour du 8 mai 2002
 Nature Neuroscience vol 3, mai 2002, p339-349
voir en français l'hypocrétine
Schematic model of neurotransmitter circuits that are involved in the three states of vigilance
 
JG Sutcliffe et L de Lecea - the hypocretins : setting the arousal threshold

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state-vigilance

During wakefulness, hypocretin(Hcrt) activity excites noradrenergic(green), histaminergic (deep blue) and serotonergic(yellow) neurons, which give rise to enhanced cortical activity and arousal. Slow-wave sleep (SWS) is characterized by synchronous intrinsic cortical activity, and most subcortical afferents show reduced activity. During rapid eye movement (REM) sleep, low hypocretin activity results in the disinhibition of REM-on cholinergic neurons (orange). DRN, dorsal raphe nucleus; LC, locus coeruleus; PPT, pedunculopontine tegmental nucleus; PRF, pontine reticular formation; TMN, tuberomammillary nucleus.
 

Hypothalamic regulation of sleep Rafael Salin-Pascual version pdf intégrale

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